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Publications

 

 

Complete list of published work at My Bibliography:

http://www.ncbi.nlm.nih.gov/pubmed/?term=Gerlic+M

 

     2020
  1. Hadar Cohen, Noam Baram, Liat Edry-Botzer, Ariel Munitz, Dor Salomon, Motti GerlicVibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome. Emerging Microbes & Infections, Feb, 2020.
     

  2. Mary Speir, Cameron J Nowell, Alyce A Chen, Joanne A O’Donnell, Isaac S Shamie, Paul R Lakin, Akshay A D’Cruz, Roman O Braun, Jeff J Babon, Rowena S Lewis, Meghan Bliss-Moreau, Inbar Shlomovitz, Shu Wang, Louise H Cengia, Anca I Stoica, Razq Hakem, Michelle A Kelliher, Lorraine A O’Reilly, Heather Patsiouras, Kate E Lawlor, Edie Weller, Nathan E Lewis, Andrew W Roberts, Motti Gerlic, Ben A Croker. Ptpn6 inhibits caspase-8-and Ripk3/Mlkl-dependent inflammationNature immunology, Jan, 2020.

    2019

  3. Nour Ershaid, Yoray Sharon, Hila Doron, Yael Raz, Ophir Shani, Noam Cohen, Lea Monteran, Leonor Leider-Trejo, Amir Ben-Shmuel, Muhammad Yassin, Motti Gerlic, Adit Ben-Baruch, Metsada Pasmanik-Chor, Roni Apte, Neta Erez. NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasisNature communication, Sep, 2019.
     

  4. Ziv Erlich, Inbar Shlomovitz, Liat Edry-Botzer, Hadar Cohen, Daniel Frank, Hanqing Wang, Andrew M Lew, Kate E Lawlor, Yifan Zhan, James E Vince, Motti GerlicMacrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model. Nature immunology, Feb, 2019.
     

  5. Inbar Shlomovitz, Ziv Erlich, Mary Speir, Sefi Zargarian, Noam Baram, Maya Engler, Liat Edry‐Botzer, Ariel Munitz, Ben A Croker, Motti GerlicNecroptosis directly induces the release of full‐length biologically active IL‐33 in vitro and in an inflammatory disease model. The FEBS Journal, Feb, 2019.

    2018

  6. Hazel Tye, Chien-Hsiung Yu, Lisa A Simms, Marcel R de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S Penington, Cassandra R Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F Wockner, Adele Preaudet, Lisa A Mielke, Stephen A Wilcox, Yasunori Ogura, Sinead C Corr, Komal Kanojia, Konstantinos A Kouremenos, David P De Souza, Malcolm J McConville, Richard A Flavell, Motti Gerlic, Benjamin T Kile, Anthony T Papenfuss, Tracy L Putoczki, Graham L Radford-Smith, Seth L Masters. NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease. Nature communication, Sep, 2018.
     

  7. Kaiwen W Chen, Kate E Lawlor, Jessica B von Pein, Dave Boucher, Motti Gerlic, Ben A Croker, Jelena S Bezbradica, James E Vince, Kate Schroder. Cutting edge: blockade of inhibitor of apoptosis proteins sensitizes neutrophils to TNF-but not lipopolysaccharide-mediated cell death and IL-1β secretion. J Immunology, May, 2018.

    2017

  8. Sisquella X, Ofir-Birin Y, Pimentel MA, Cheng L, Abou Karam P, Sampaio NG, Penington JS, Connolly D, Giladi T, Scicluna BJ, Sharples RA, Waltmann A, Avni D, Schwartz E, Schofield L, Porat Z, Hansen D, Papenfuss AT, Eriksson EM, Gerlic M, Hill AF, Bowie AG and Regev-Rudzki N. Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors. Nature Communication, Dec, 2017.
     

  9. Ralph M, Bednarchik M, Tomer E, Rafael D, Zargarian S, Gerlic M, Kobiler O. Promoting Simultaneous Onset of Viral Gene Expression Among Cells Infected with Herpes Simplex Virus-1. Frontiers in Microbiology, Nov, 2017. 
     

  10. McArthur K, D'Cruz AA, Segal D, Lackovic K, Wilks AF, O'Donnell JA, Nowell CJ, Gerlic M, Huang DCS, Burns CJ, Croker BA. Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia. Oncotarget. Aug, 2017 . 
     

  11. Zargarian S, Shlomovitz I, Erlich Z, Hourizadeh A, Ofir-Birin Y, Croker BA, Regev-Rudzki N, Edry-Botzer L, Gerlic M. Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis. PLoS Biology, Jun, 2017. 

    2016

  12. Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL. IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome. Cell Metabolism, Jan, 2016. 

    2015

  13. Uboldi AD, McCoy JM, Blume M, Gerlic M, Ferguson DJ, Dagley LF, Beahan CT, Stapleton DI, Gooley PR, Bacic A, Masters SL, Webb AI, McConville MJ, Tonkin CJ. Regulation of Starch Stores by a Ca(2+)-Dependent Protein Kinase Is Essential for Viable Cyst Development in Toxoplasma gondii. Cell Host Microbe. Dec, 2015. 
     

  14. Blume M, Nitzsche R, Sternberg U, Gerlic M, Masters SL, Gupta N, McConville MJ. The gluconeogenic enzyme fructose bisphosphatase regulates glucose catabolism in Toxoplasma gondii and is essential for replication and virulence, Cell host & Microbe, Aug, 2015. 
     

  15. Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D’Cruz AA, Hall C, Spall SK, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WWL, Silke J, Vaux DL, Vince JE. RIPK3 promotes cell death, NLRP3 inflammasome and interleukin-1 activation in the absence of MLKL, Nature Communication, Feb, 2015. 

    2014

  16. O’Donnell JA, Kennedy CL, Pellegrini M, Nowell CJ, Cengia L, Masters SL, Hartland EL, Roberts AW, Gerlic M, Croker BA. Fas controls neutrophil lifespan during viral and bacterial infection. Journal of Leukocyte Biology, Dec, 2014. 
     

  17. Rickard JA*, O’Donnell JA*, Evans JM*, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts AW, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker BA*, Gerlic M*#, Silke J*#. RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis. Cell, May, 2014 *These authors contributed equally to this work. # Corresponding authors. 
     

  18. Correa RG, Krajewska M, Ware CF, Gerlic M, Reed JC. The novel NLR-related protein NWD1 is associated with prostate cancer progression and impacts androgen receptor signalling. Oncotarget. Mar, 2014. 
     

  19. Gerlic M, Croker BA, Cengia LH, Moayeri M, Kile BT, Masters SL. NLRP1a expression in Srebp1a deficient mice. Cell Metabolism, Mar, 2014.
     

    2013

  20. Gerlic M*, Faustin B*, Postigo A, Yu ECW, Gombosuren N, Krajewska M, Flynn R, Croft M, Way M, Satterthwait A, Liddington RC, Salek-Ardakani S, and Reed JC. Vaccinia Virus F1L protein promotes virulence by inhibiting NLR inflammasome activation. PNAS, Apr, 2013. *These authors contributed equally to this work. PMID: 23603272

    2012

  21. Proell M, Gerlic M, Mace PD, Reed JC, Riedl SJ. The CARD plays a critical role in ASC foci formation: New insights into inflammasome signaling. Biochem Journal, Oct, 2012. 
     

  22. Masters SL*, Gerlic M*, Metcalf M, Preston S, Pellegrini M, O’Donnell JA, McArthur K, Baldwin TM, Chevrier S, Nowell CJ, Cengia LH, Henley KJ, Collinge JE, Kastner DL, Feigenbaum L, Hilton DJ, Alexander WS, Kile BT*, Croker BA*. NLRP1 inflammasome induces pyroptosis of hematopoietic progenitor cells. Immunity, Dec, 2012. *These authors contributed equally to this work. PMID: 23219391
     

  23. Haneklaus M, Gerlic M, Kurowska-Stolarska M, Rainey AA, Pich D, McInnes IB, Hammerschmidt W, O'Neill LA, Masters SL. Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production. J Immunology. Oct, 2012.

    2011

  24. Correa RG, Khan PM, Askari N, Zhai D, Gerlic M, Brown B, Magnuson G, Spreafico R, Albani S, Sergienko E, Diaz PW, Roth GP, Reed JC. Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors. Chem Biol. Jul, 2011.
     

  25. Yu E, Zhai D, Jin C, Gerlic M, Reed JC, Liddington R. Structural determinants of caspase-9 inhibition by the vaccinia virus protein, F1L. J Biol Chem. Sep, 2011.
     

  26. Garrison JB, Correa RG, Gerlic M, Yip KW, Krieg A, Tamble CM, Shi R, Welsh K, Duggineni S, Huang Z, Ren K, Du C, Reed JC. ARTS and Siah collaborate in a pathway for XIAP degradation. Mol Cell. Jan, 2011. 

    2008

  27. Yip KW, Godoi PH, Zhai D, Garcia X, Cellitti JF, Cuddy M, Gerlic M, Chen Y, Satterthwait A, Vasile S, Sergienko E, Reed JC. A TR3/Nur77 peptide-based high-throughput fluorescence polarization screen for small molecule Bcl-B inhibitors. J Biomol Screen. Aug, 2008. 

    2007

  28. Gerlic M, Horowitz J, Farkash S, Horowitz S. The inhibitory effect of Mycoplasma fermentans on tumour necrosis factor (TNF)-alpha-induced apoptosis resides in the membrane lipoproteins. Cell Microbiol. Jan, 2007. 

    2004

  29. Gerlic M, Horowitz J, Horowitz S. Mycoplasma fermentans inhibits tumor necrosis factor alpha-induced apoptosis in the human myelomonocytic U937 cell line. Cell Death Differ. Nov, 2004. 

Contact Details

Prof. Motti Gerlic, PhD


Department of Clinical Microbiology and Immunology 
Sackler School of Medicine
Tel Aviv University

Tel Aviv 69978

Israel

Phone (Office):+972-3-6409400

Phone (Lab):+972-3-6409069

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